ALEXANDER R. VAN VLIET
Publications
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First/Corresponding Author Research articles
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation
Alexander R. van Vliet*, George N Chiduza*, Sarah Maslen, Val Pye, Dhira Joshi, Stefano De Tito, Harold BJ Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H. Hervás, Nicola O’Reilly, Mark Skehel, Peter Cherepanov, Sharon A. Tooze
Molecular Cell – DOI 10.1016/j.molcel.2022.10.017
*These authors contributed equally to this work.
Imaging and tracking ATG9A, a multi-spanning membrane protein
Alexander R. van Vliet*, Stefano De Tito*, Eugenia Almacellas*, Sharon A. Tooze
Journal of Visual Experiments, Manuscript in revision.
*These authors contributed equally to this work.
Interactome Analysis of the ER Stress Sensor PERK uncovers key components of ER-mitochondria contact sites and Ca2+ signaling.
Maria Livia Sassano, Rita Derua, Etienne Waelkens, Patrizia Agostinis±, Alexander R. van Vliet± (2021)
Contact, Volume 4 – DOI: 10.1177/25152564211052392
±Co-corresponding author
The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling
Alexander R. van Vliet, Francesca Giordano, Sarah Gerlo, Inmaculada Segura, Sofie van Eygen, Geert Molenberghs, Susana Rocha, Audrey Houcine, Rita Derua, Tom Verfaillie, Jeroen Vangindertael, Herlinde De Keersmaecker, Etienne Waelkens, Jan Tavernier, Johan Hofkens, Wim Annaert, Peter Carmeliet, Afshin Samali, Hideaki Mizuno, Patrizia Agostinis (2017)
Molecular Cell - DOI: 10.1016/j.molcel.2017.01.020.
-Selected as a research highlight by Nature Reviews Molecular Cell Biology, 18, 213 (2017) doi:10.1038/nrm.2017.31
Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim
Tom Verfaillie*, Alexander van Vliet*, Abhishek D. Garg, Michael Dewaele, Noemi Rubio, Sanjeev Gupta, Peter de Witte, Afshin Samali, Patrizia Agostinis (2013)
Biochemical and Biophysical Research Communications - DOI:10.1016/j.bbrc.2013.07.107
*These authors contributed equally to this work.
Co-Authored Research articles
PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration.
Maria Livia Sassano, Alexander R. van Vliet, Ellen Vervoort, Sofie Van Eygen, Chris Van den Haute, Benjamin Pavie, Joris Roels, Johan V. Swinnen, Marco Spinazzi, Leen Moens, Kristina Casteels, Isabelle Meyts, Paolo Pinton, Saverio Marchi, Leila Rochin, Francesca Giordano, Blanca Felipe-Abrio*, Patrizia Agostinis* (2023)
Journal of Cell Biology - 10.1083/jcb.202206008
*Co-corresponding author
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.
Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J Kaufman, Nibaldo C Inestrosa, Christian Gonzalez-Billault, R Luke Wiseman, Patrizia Agostinis, Geert Bultynck, Felipe A Court, Guido Kroemer, J César Cárdenas, Claudio Hetz (2019)
Nature Cell Biology – DOI: 10.1038/s41556-019-0329-y
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.
EV-TRACK Consortium, Van Deun J, ..... Hendrix A. (2017) (86th author, of 97 total authors)
Nat Methods. - DOI: 10.1038/nmeth.4185.
ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function.
Romain Galmes*, Audrey Houcine*, Alexander R. van Vliet, Patrizia Agostinis, Catherine L. Jackson, and Francesca Giordano (2016)
EMBO Reports, - DOI 10.15252/embr.201541108
*These authors contributed equally to this work.
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.
Javed Manesia, Zhoufei Xu, Dorien Broekaert, Ruben Boon, Alexander van Vliet, Thomas Vanwelden, Guy Eelen, Alberto Pascual-Montano, Sarah Maria-Fendt, Geert Carmeliet, Peter Carmeliet, Satish Khurana, Catherine M. Verfaillie (2015)
Stem Cell Research - DOI:10.1016/j.scr.2015.11.001.
The BH4 domain of Bcl-XL, but not that of Bcl-2, limits the voltage‐dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ to mitochondria.
Giovanni Monaco*, Elke Decrock*, Nir Arbel, Alexander R. van Vliet, Rita La Rovere , Humbert De Smedt, Jan B. Parys, Patrizia Agostinis, Luc Leybaert, Varda Shoshan-Barmatz, Geert Bultynck (2014)
Journal of Biological Chemistry, - DOI: 10.1074/jbc.M114.622514
*These authors contributed equally to this work.
Review articles
The Golgi as an assembly line to the autophagosome.
Stefano de Tito*, Javier H. Hervás*, Alexander R. van Vliet*, Sharon A. Tooze (2020)
Trends in Biochemical Sciences. - DOI: 10.1016/j.tibs.2020.03.010
*These authors contributed equally to this work.
Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.
Christopher J. Stefan, William S. Trimble, Sergio Grinstein, Guillaume Drin, Karin, Pietro De Camilli, Sarah Cohen, Alex M. Valm, Jennifer Lippincott-Schwartz, Tim P. Levine, David B. Iaea, Frederick R. Maxfield, Clare E. Futter, Emily R. Eden, Delphine Judith, Alexander R. van Vliet, Patrizia Agostinis, Sharon A. Tooze, Ayumu Sugiura and Heidi M. McBride (2017)
BMC Biol. - DOI: 10.1186/s12915-017-0432-0.
Mitochondria-Associated Membranes as Networking Platforms and Regulators of Cancer Cell Fate.
Maria Livia Sassano, Alexander R. van Vliet, Patrizia Agostinis (2017)
Front Oncol. - DOI: 10.3389/fonc.2017.00174 017.
PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact site.
Alexander R. van Vliet, Patrizia Agostinis (2017)
Molecular and Cellular Oncology - http://dx.doi.org/10.1080/23723556.2017.1340105.
Mitochondria-Associated Membranes and ER Stress.
Alexander R. van Vliet, Patrizia Agostinis (2017)
Curr Top Microbiol Immunol. - DOI: 10.1007/82_2017_2.
When under pressure, get closer: PERKing up membrane contact sites during ER stress.
Alexander R. van Vliet, Patrizia Agostinis (2016)
Biochemical Society Transactions - DOI: 10.1042/BST20150272.
Alexander R. van Vliet, Abhishek D. Garg, Patrizia Agostinis (2016)
Biological Chemistry, DOI: 10.1515/hsz-2016-0108.
Alexander R. van Vliet*, Shaun Martin*, Abhishek D. Garg, Patrizia Agostinis (2015)
Seminars in Cancer Biology, - DOI:10.1016/j.semcancer.2015.03.010 *These authors contributed equally to this work.
New functions of mitochondria associated membranes in cellular signaling
Alexander R. van Vliet, Tom Verfaillie, Patrizia Agostinis (2014)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research -DOI:10.1016/j.bbamcr.2014.03.009.